Sorption and releasing of ceftriaxone in biological fluids with synthesis and modification of magnetic nanoparticles

چکیده مقاله

In this research, a novel method is reported for the surface grafting of n-vinylcaprolactam as a thermosensitive agent and 3-allyloxy-1,2propandiol with affinity toward ceftriaxon onto modified magnetite nano-particles by 3-mercaptopropyltrimethoxysilane[1]. The grafted nanoparticles were characterized by Fourier transform infrared spectroscopy and elemental analysis. The surface morphology was studied using Scanning Electron Microscopy. The resulting grafted nanoparticles were used for the determination of trace ceftriaxone in biological human fluids[2]. The profile of ceftriaxone uptake by the modified magnetic nanoparticles indicated good accessibility of the active sites in the grafted copolymer. It was found that the adsorption behavior could be fitted by the Langmuir adsorption isotherm model. Solid phase extraction for biological fluids such as urine and serum were investigated

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