Multiplexed microarrays based on optically encoded microbeads

چکیده مقاله

In recent years there has been growing interest in using encoded functionalized microbeads as a solid support to capture proteins or nucleotides which act as diseases biomarkers. Multiplexing technologies (suspension array and planar array) based on optically encoded microspheres make possible the observation of small changes relates to specific diseases. Identifying the small alterations corresponding to an incurable disease provide the ability to detect the disease in the early stages. As the accuracy of current diagnostic methods to predict some diseases is generally quite low, multiplexed assays based on optically encoded microbeads could play a key role to detect biomarkers of diseases in an invasive and accurate way. However, detection system based on functionalized encoded microbeads is an emerging technology and more researches needed to be done in the future. This review paper is a preliminary attempt to collect all necessary data around microbeads; from microsphere composition, synthesis and encoding methods to microbeads based detection systems and applications

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