Preparation of gazlin Imprinted Nanospheres as Novel Drug Delivery System

چکیده مقاله

in the present work, molecularly imprinted polymers (MIPs) nanosphere for gazlin have been synthesized by precipitation polymerization. The  molecularly  imprinted  nanospheres  were prepared using gazlin as the template molecule, methacrylic acid (MAA) as a functional monomer and trimethylolpropane trimethacrylate (TRIM) as a cross-linker.Morphological properties were determined by scanning electron microscopy (SEM) and the binding properties of the imprinted nanospheres were studied by equilibrium binding test. The applicability of the obtained materials as drug delivery devices was evaluated by performing in vitro release studies. gazlin loading and  release  experiments demonstrated that the MIPs nanospheres exhibited a higher loading capacity and a much longer period of sustained gazlin release than non-imprinted polymers (NIPs) nanospheres due to the interaction of gazlin  with  the  gazlin  -imprinted  cavities  within  the  MIPs  nanospheres.  The MIPs nanospheres exhibited a good controlled gazlin release profile. This new MIPs nanospheres can utilize as a novel drug delivery devices due to its improved properties.

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