- تاریخ انتشار : ۱۳۹۵
- ناشر : کنفرانس بین المللی علوم و مهندسی در عصر تکنولوژی
- زبان مقاله : همه
- تعداد صفحات : 10
- حجم فایل : 380.815 کیلوبایت
- نوع مقاله : مجموعه مقالات کنفرانس
- مجموعه : پزشکی
چکیده مقاله
The main purpose of this study was preparation of a pharmaceutical formulation with etoposide loaded Poly Butyl Cyano Acrylate (PBCA) nanoparticles and evaluation of its effect on brain cancer. Etoposide loaded nanocarrier was synthesized using micro-emulsion polymerization method and characterized for shape morphology, particle size, zeta potential and drug-release properties. In the next step, BE (2)-C brain cell line was used to determine the rate of nanocarrier etoposide cytotoxicity.Etoposide loaded nanoparticles were characterized and size and zeta potential of nanoparticles containing drugs were measured as 225.3 ± 21.7 nm and -26.3 ± 1.5 mv, respectively. Drug loading and encapsulation values were estimated 8.7± 0.15 and 97.3±2.1%, respectively. The release amount of drug from PBCA nanoparticles indicated the retention strength corresponding to the formulation. Cytotoxicity studies showed that the cell toxicity effect of drug loaded PBCA nanoparticles is almost two times higher than the free drugs. Finally, it was found that the obtained formulation has a proper stability and drug maintain its stability after storage in 4 for two months. According to the obtained results, this nanoparticle has a potential to be used as a drug delivery system.
نحوه استناد به مقاله
در صورتی که می خواهید به این مقاله در اثر پژوهشی خود ارجاع دهید، می توانید از متن زیر در بخش منابع و مراجع بهره بگیرید :
Elham Rajabi pour ؛Maral Mazloumi tarbrizi ؛Nasim Saeedi ؛Azim Akbarzadeh khiyavi ؛Rohollah Heydari ؛Leila Kanaani* ؛ ۱۳۹۴، Preparation of Etoposide Loaded Poly butyl Cyano Acrylate Nanoparticles and It’s Effect on Human Brain Carcinoma Cells BE(2)-C، کنفرانس بین المللی علوم و مهندسی در عصر تکنولوژی، https://scholar.conference.ac:443/index.php/download/file/11434-Preparation-of-Etoposide-Loaded-Poly-butyl-Cyano-Acrylate-Nanoparticles-and-It’s-Effect-on-Human-Brain-Carcinoma-Cells-BE(2)-C
در داخل متن نیز هر جا به عبارت و یا دستاوردی از این مقاله اشاره شود پس از ذکر مطلب، در داخل پرانتز، مشخصات زیر نوشته شود.
(Elham Rajabi pour ؛Maral Mazloumi tarbrizi ؛Nasim Saeedi ؛Azim Akbarzadeh khiyavi ؛Rohollah Heydari ؛Leila Kanaani* ؛ ۱۳۹۴)