An Efficient one pot Synthesis of new Polysubstituted Hetrocyclic Ring System 4-Aroyl-3-Cyanoquinoline Derivatives via a Sequential Four Component Reaction

چکیده مقاله

A new library of 3-Cyanoquinoline containing an aroyl group has been developed by sequential four-component reaction of dimedone, various aniline, aryl glyoxal with malononitrile under mild conditions in the melt and ethanol in sequence. The protocol for the synthesis of novel polysubstituted Quinoline is distinguished by its high atom-economy; yield the desired products in good to excellent yields, the use of ethanol as reaction media, and the efficiency of production without the use of any activator or metal promoters.

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