Light and Electron Microscopic investigation of Semelil

چکیده مقاله

One of the main therapeutic intentions of modern cardiology is to contrive strategies aimed at decreasing myocardial necrosis and improving cardiac healing following myocardial infarction (MI). This investigation was contrived to study the protective effects of Semelil (ANGIPARS™), a native herbal medicine, on MI in the rabbit model. Twenty-five New Zealand white rabbits were utilized in this investigation. Rabbits were allocated to equal groups: control plus vehicle; sham; sham plus vehicle; ischemia plus vehicle; Semelil 10 mg/kg, respectively. MI was created by the complete closure of Left Anterior Descending Coronary Artery (LADC). The animals were treated with Semelil 10 mg/kg daily for 14 days. Electrophysiological, Biochemical, histological and ultrastructural studies were used for detecting protective effects of Semelil. Based on our data, Semelil ameliorated the ECG pattern. Besides, treatment with Semelil improved levels of Creatine Kinase, creatine kinase isoenzyme and Lactate dehydrogenase comparing to the ischemia group. Morphological data showed that Semelil could protect cardiomyocytes against myocardial infarction insults. The results indicate that Semelil may have protective effects against ischemic damages induced by LAD obstruction in male rabbits due to its anti-inflammatory and antioxidant properties.

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