The Role of H2 histaminergic receptor on contractions of isolated rat’s male ileum

چکیده مقاله

Introduction: to elucidate the role of the histamine receptor in function relate intestinal motility in this study investigate the effects of histamine and antagonists H2 receptor (Cimetadine) on contractions of adult male rat’s ileum. Methods: In this study, 2 cm from the terminal isolated adult male rat’s ileum Tyrode solution in an organ bath containing oxygenated (370c , PH=7.4) and placed under 1 gram tension contractions induced by 60mM potassium chloride and histamine concentrations (0.0001, 0.001, 0. 01, 0. 1mg/ml) and cimetidine Concentrations (0.002, 0.004, 0.008 mg/ml) were added to the organ bath And their effects on the ileum contractions were recorded by using Harvard oscilogrf. Results: Our findings indicate that the Histamine concentration (0.1 mg/ml) as an agonist caused a significant contraction (p< 0/001) while concentration Cimetidine(0.004 mg/ml) as an H2 antagonist of the histaminergic system reduced (p < 0/05) and Concentrations (0.002, 0.008 mg/ml) did not change the ileum contractions. Conclusion: According to our findings, Histamine by receptors increases the contractions while Cimetidine (0.004 mg/ml) (Histamine H2 receptor blocker) reduced the contractions in adult male rats’ ileum .

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