![Homology modeling and topology prediction of FrpB protein in Neisseria meningitidis Homology modeling and topology prediction of FrpB protein in Neisseria meningitidis](https://scholar.conference.ac/images/ConferencesAC_img_a7704316449faa89a7d73feb221e13b6.jpg)
- تاریخ انتشار : ۱۳۹۵
- ناشر : سومین کنفرانس بین المللی پژوهش در علوم و تکنولوژی
- زبان مقاله : همه
- تعداد صفحات : 16
- حجم فایل : 538.771 کیلوبایت
- نوع مقاله : مجموعه مقالات کنفرانس
- مجموعه : علوم پایه
چکیده مقاله
Iron is an essential nutrient for almost all bacteria, but the concentration of free iron in the human host is too low to support growth. In the extracellular compartments of the human body, iron is bound mainly to transferr and lactoferrin. Many bacteria deal with iron limitation by the secretion of siderophores, which are small organic compounds that bind iron very efficiently. The Fe31-siderophore complex is bound to specific receptors on the bacterial cell surface and internalized. The transport across the outer membrane requires energy,which is provided in Escherichia coli by the inner membrane protein TonB. FrpB is another iron-limitation inducible outer membrane protein of Neisseria meningitidis. Its function is unknown. Previously, monoclonal antibodies was raised against this protein, most of which appeared to be bactericidal in an in vitro assay with human complement.Here we describe the topology and 3D structure of a novel antigen which was discovered by mining the bacterial genome and that is very effective in inducing bactericidal antibodies. This antigen is a very good candidate for inclusion in universal vaccines against N.meningitidis.
نحوه استناد به مقاله
در صورتی که می خواهید به این مقاله در اثر پژوهشی خود ارجاع دهید، می توانید از متن زیر در بخش منابع و مراجع بهره بگیرید :
Fateme Al Sadat Hosseini؛Fateme Sefid؛mahnaz mashroteh؛marjan babadi؛ ۱۳۹۴، Homology modeling and topology prediction of FrpB protein in Neisseria meningitidis، سومین کنفرانس بین المللی پژوهش در علوم و تکنولوژی، https://scholar.conference.ac:443/index.php/download/file/7127-Homology-modeling-and-topology-prediction-of-FrpB-protein-in-Neisseria-meningitidis
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(Fateme Al Sadat Hosseini؛Fateme Sefid؛mahnaz mashroteh؛marjan babadi؛ ۱۳۹۴)