linear B-cell epitope prediction for S1 protein of Infectious Bronchitis Virus

چکیده مقاله

Infectious Bronchitis is a contagious respiratory disease caused by Infectious Bronchitis Virus (IBV). One of the structural proteins of the virus is S1 protein which is very variable and its variety contributing to poor cross-protection between serotypes causes the need for vaccine development using the prevalent serotype in a given region which could be time-consuming and expensive protocol. Due to the time-consuming nature of live attenuated vaccine development process, in the current study we tried to introduce some linear B-cell epitopes for the S1 subunit belonging to strain ck/CH/LSD/110311 attained from NCBI with the hope that it could combat with one or some specific serotypes of IBV as epitope vaccine. Epitope prediction was carried out using some of the most important features of proteins including antigenicity and physicochemical properties (hydropathy, flexibility and accessibility) through different online softwares. Finally eight universal linear B-cell epitopes of the S1 protein of IBV were introduced.

دریافت لینک دانلود مقاله