Increased risk of childhood Acute Lymphoblastic Leukemia (ALL) by prenatal and postnatal exposures to high voltage power lines: A case control study in Isfahan-Iran

چکیده مقاله

Childhood Acute Lymphoblastic Leukemia (ALL) has been considered as the most common hematologic malignancy which accounts for one fourth of all childhood cancer cases. Exposure to environmental factors around the time of conception or pregnancy can increase the risk of ALL in the offspring .This study aimed to evaluted the role of prenatal and postnatal exposure to high voltage power lines  on the incidence of childhood ALL.This cross-sectional case control study was carried out on 22 cases and 100 controls who born and lived in low socioeconomic families in Isfahan and hospitalized for therapeutic purposes in different hospitals of Isfahan from 2013-2014 .With regard to the underlying risk factors; familial history and parental factors were detected as risk factors of ALL  but  in this age ,socioeonomic and zonal matched case control study, prenatal and childhood exposure to high voltage power lines was considered as the most important  environmental risk factors of ALL(p=0.006,OR=3.651,CI95%1.692-7.878). As the population study was from low socioeconomic state, using mobiles, computers, microwave was negligible. Moreover prenatal and postnatal exposure to all indoor electrically charged objects were not detected as significant environmental factors in present study. This work has defined the forces of environmental exposures especially continuous pre and post natal exposure to high voltage power lines and living in pollutant regions through the parents or children as well as the role of previously described risk factors of ALL for the first time in low socioeconomic Iranian population.

دریافت لینک دانلود مقاله